81377 München christian.haass(at)dzne.de +49 89 4400-46549 Areas of investigation/research focus Prof. Haass started to work on Alzheimer's disease (AD) in 1990 at a time, when very little welches known about the cellular mechanisms involved. Based on the pathology, which shows invariably the accumulation and deposition of Amyloid ß-peptide (Aß), he focused his work on the generation and metabolism of Aß. Christian Haass hypothesized against the widely accepted general opinion rein this field that Aß may be produced from its precursor rein a physiologically üblich pathway and not necessarily rein a pathological process. Indeed he found by using very simple tissue culture systems that Aß is produced and liberated under physiological conditions. This pivotal finding was a major breakthrough for the entire field, since it allowed elucidating the molecular principles behind Aß generation as well as the identification of the enzymes (the so-called secretases) involved in generation and liberation of the peptide and finally the development of selective inhibitors to therapeutically lower Aß production hinein patients.
We are using interdisciplinary approaches ranging from biophysics, biochemistry and cellular and molecular biology to hinein vivo models and life imaging.
We are the new, modern Munich driving school for Schwabing and Maxvorstadt. On three evenings a week, our fully-equipped driving school will give you the opportunity to become familiar with the theory – quickly and thoroughly.
Christian Haass, Professor of Metabolic Biochemistry at LMU Munich and spokesperson for the DZNE Munich, is known for his groundbreaking research in Alzheimer's disease. His work focuses on the molecular and cellular mechanisms of this disease in order to gain fundamental insights into its development.
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If you are lacking driving practice or simply haven't driven a car rein a long time and have got out of the habit, we can help you get back into it with a few refresher lessons.
Rein addition, you can use ur „Learning to drive“ app to extend your knowledge – wherever and whenever you wish. With this mix of classroom study and app training you will be fully prepared for the theoretical test.
At the earliest, approx. 3 – 5 months before your 18th birthday, depending on whether you wish to do the theoretical and the practical Schulung one after the other or at the same time.
Inhibition of secretases as a therapeutic approach requires detailed knowledge about the physiological functions and biochemical properties of these enzymes to avoid unwanted side effects. Christian Haass welches the first to demonstrate a physiological function for beta-secretase. He showed that this protease is critically required for the regulation of myelination. Furthermore, he identified a novel APP processing pathway, which welches overlooked for more than 20 years and which has strong implications for clinical trials using beta-secretase inhibitors. He welches also the first to identify the highly complicated subunit composition of gamma-secretase. All these findings not only helped to understand several signaling pathways critically involved hinein brain development (such as myelination and cell differentiation) but also provided the basis for several current therapeutic approaches.
Momo’s Driving School in Munich also offers refresher courses for licence-holders Weltgesundheitsorganisation want to optimise their driving skills or Weltgesundheitsorganisation have not driven for a long time and want to gather practical driving experience accompanied by a driving instructor.
Our learning-type check helps you to learn how to learn more efficiently. Success may be improved rein a short time.
We will give you driving lessons designed to suit your own particular needs not only during the week but also on Saturdays. Rein this way you will get your driving licence as quickly as possible.
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If you are lacking driving practice or simply haven't driven a car hinein a long time and have got out of the habit, we can help you get back into it with a few refresher lessons.